BET Bromodomain Inhibitors OTX015 Promote Killing of Hepatocellular Carcinoma Cells through Pharmacological Effect and By Inhibiting the Expression of Programmed Death Ligand-1

Bromodomain and extra-terminal domain inhibitors target bromodomain-containing proteins are currently being evaluated as anti-cancer agents. In this study, we found that bromodomain extraterminal inhibitor OTX015 can effectively inhibit the proliferation of hepatocellular carcinoma cells promote apoptosis cells. At same time, anticancer effect is better than JQ1, a similar inhibitor. addition, also OTX015, like JQ1 expression programmed death-ligand 1 in induced by interferon alpha. We demonstrated inhibition was achieved inhibiting binding protein to promoter transcriptional activity 1. When treated with inhibitor, peripheral blood mononuclear kill Finally, detected levels protein, 2, 4 patient samples. The results showed 2 were correlated some patients. Therefore, may be small molecule drug dual anti-tumor effects.